Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA
Abstract Background Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination.The scale of these costs is highly variable.Some, including resistance of Staphylococcus aureus to the clinically important antibiotic mupirocin, have been reported as being cost-free, which Welding Helmets suggests t